A Team for Accelerating Catalyst and Reaction

Abstract This invited Team Profile was created by the Gessner and Gooßen research groups at Ruhr-University Bochum (Germany). They recently published a series of articles in Angewandte Chemie on application ylide-substituted phosphines (YPhos) palladium-catalyzed coupling reactions. Owing to their inherently strong sigma-donating ability modular synthesis, YPhos ligands can be tailored fit demands various catalytic transformations. In most recent article, machine learning methods were applied identify catalyst that enables previously elusive Hiyama aryl chlorides. “Computer-Driven Development Ylide Functionalized Phosphines for Palladium-Catalyzed Couplings”, J. F. Goebel, Löffler, Z. Zeng, Handelmann, A. Hermann, I. Rodstein, T. Gensch, V. H. Gessner, L. Gooßen, Angew. Chem. Int. Ed. 2023, e202216160; e202216160.